Improving your health ‒ starting with the gut microbiome

Research on the effect of nutrients

The human gut microbiome is as unique as our fingerprint. We inherit it from birth and once formed, it is difficult to change. However, external factors such as nutrition may well offer a chance to do so. Our gut health team not only analyses the functioning of the gut microbiome works, but also investigates the effect of nutrients on this complex system of microorganisms and our overall health.

Unlocking solutions for better gut health

A team of TNO specialists from different fields work closely together on microbiology, gut tissue, bioinformatics and business development, aiming to gain new insights into gut health. They have been busy developing innovative tools, partnering with other frontrunners for example in the food and pharma industries, and unlocking a wide range of solutions for better gut health, from diagnostics to therapeutic interventions.

Unique approach inside and outside the lab

TNO has been researching and forging partnerships in this field for decades, giving us the experience to develop models that closely resemble humans and can be tailored to specific research questions. Unique to our approach is that we combine microbiome and living gut tissue in a single model. In addition to these two pillars, we also include biology in our research. This means we look outside the lab and monitor people’s actual health, for example through questionnaires.

Relevant research fields for various target groups

TNO leads innovative projects focused on improving gut health that are of interest to health care professionals and companies in industries such as food, biotech and pharmaceuticals. One of our research areas focuses on the gut-brain axis, exploring how gut health impacts mental health and how nutrition can help. Another area of research is the effectiveness of pre- and probiotics to improve immune function and prevent gut inflammation. A third area is customised nutritional solutions: how can we personalise products based on individual gut microbiome profiles?

Advanced tools

To investigate the complex relationship between the gut microbiome and human health, TNO uses state-of-the-art tools including:

• i-screen: for in vitro testing of the interaction between nutrients and microbiota
• InTESTine: a model for studying the functioning of gut tissue, such as nutrient absorption, gut barrier function and the release of satiety hormones
• AI models that recognise patterns and predict health outcomes
• Apps that remotely monitor the effects on physical and mental health

Impact on more than just health

TNO’s models and tools provide a quick insight into the effect of certain ingredients or drugs on the gut microbiome and our overall health. This way, they help prevent disease, improve care,

reduce healthcare costs and promote personalised care. Another key benefit is that they help to reduce the need for animal testing.

Make more impact with TNO

Do you work at a biotech company developing a new drug, a food company exploring the benefits of prebiotics, or are you a healthcare professional seeking a deeper understanding of gut health? Make more impact by partnering up with TNO.

We are currently putting together an innovative consortium that aims to gain more insight into the interaction between microbes and dietary fibre. Join us now to improve dietary fibre applications for a healthier gut microbiome and take a leap towards better overall health. Please contact us for more information.