Organ on a chip

TNO has a long  track record in understanding the biology in disease development and drug PK and metabolism. In the last 5 years TNO invested in connecting those two with its expertise in Organ on a chip technology to find its application in better predictive, non-animal alternatives for drug efficacy and ADME testing.

This has led to the development of a liver on a chip model to test drug efficacy (in NASH/fibrosis) as well as an InTESTine on a chip model to study ADME and the effects of microbiome on drug metabolism.